Four people sustained serious injuries when a side tipper truck collided with a minibus taxi on the N1, about 10km from Touws River towards Laingsburg, on Tuesday afternoon.
According to reports, the impact caused both drivers to lose control, resulting in the vehicles veering off the road and overturning.
Three passengers from the minibus taxi were seriously injured, while the truck driver also suffered serious injuries.
Emergency services responded swiftly to the scene, stabilising the injured before transporting them to the hospital for further care.
The cause of the crash is still under investigation.
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