One man was killed and three others injured this on Tuesday morning when a chemical tanker truck and two light motor vehicles collided on the N1 northbound between William Nicol and Rivonia.
One of the cars burst into flames upon colliding with the truck.
A chemical truck was lying on its side on the side of the road while two light motor vehicles were a short distance away, one well alight and another on its roof.
It is understood that medics had pulled a man and woman from the burning vehicle.
Medics assessed the patients and found that the man from the burning vehicle had already succumbed to his burn wounds while the woman was in a critical condition.
The truck driver was found lying on the highway in a serious condition while another woman from the overturned vehicle had escaped with minor injuries.
Medics treated the patients and provided them with advanced life support interventions before they were transported to nearby hospitals for further care.
Local authorities were on the scene for further investigations.